Find out how HELM can transform your storage of molecule information

Reference implementation

The power of HELM shown in a range of free tools


Join the project or connect with experts who can help you adopt HELM


Try the HELM Editor and HAbE, and find specifications, links to the code, user guides & presentations

Recent HELM Updates

Calling developers and informaticians!

Test your creativity and take on one of these HELM-related challenges. Each one is conceptually interesting and should be fun to solve.

What is HELM?

HELM (Hierarchical Editing Language for Macromolecules) enables the representation of a wide range of biomolecules...

antibody drug conjugates,

...whose size and complexity render existing small-molecule and sequence-based informatics methodologies impractical or unusable.

Why HELM Notation?

  • Supports all biomolecules in a single notation
  • Facilitates information exchange between organisations
  • Compact and flexible

Download the free toolkit, editors and more

Also available: search proof of concept and starter pack of monomers.

  • Create your own applications using the functionality in the toolkit.
  • Draw and convert structures into HELM using the editor.
  • Visualise antibodies, manipulate the structures and analyse domains using HAbE.
  • Source code and compiled versions available


HELM relies on an active voluntary community. We are currently supported by the following companies.

Contact Us

Ask us questions, send comments, get in touch. We love to support HELM adopters.


Links to the HELM code, user guides, videos, specifications and more can be found on our wiki.