HELM Notation

HELM was first conceived at Pfizer in the summer of 2008 to support the Pfizer oligonucleotide therapeutic unit and molecules were first registered into the Pfizer corporate database using HELM in December 2008.

HELM was designed to create a single notation that can encode the structure of all biomolecules.

HELM Components

Notation Unwrapped

Flexibility

Linear oligonucleotides

HELMNotationExample1

Cyclic peptide

HELMNotationExample2

siRNA

HELMNotationExample3

Oligonucleotide peptide conjugate

HELMNotationExample4

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Resources

Links to the HELM code, user guides, videos, specifications and more can be found on our wiki.