Notation
Find out how HELM can transform your storage of molecule information
Reference implementation
The power of HELM shown in a range of free tools
Community
Join the project or connect with experts who can help you adopt HELM
Resources
Try the HELM Editor and HAbE, and find specifications, links to the code, user guides & presentations

Recent HELM Updates

HELM editor: free at last!

The Pistoia Alliance HELM project has made two major announcements that help cement the reputation of HELM as the de-facto standard for describing and working with complex macromolecular structures. Firstly, HELM users can now take advantage of free MarvinBeans 5.0 licenses for the HELM toolkit. Secondly, RDKit is now HELM-enabled, making it a valuable addition to the extensive range of open source HELM-enabled tools.

RFP published: HELM Ambiguity and Web-services

The HELM (Hierarchical Editing Language for Macromolecules) 2.0 project has published an RFP that aims to implement a number of enhancements to the current HELM definition and open source codebase.

HELM attracting attention at Bio-IT World 2015

Having won the 2014 Best Practice Award at the Bio-IT World Conference & Expo, HELM again attracted plenty of attention at this year’s meeting (Boston, April 21-23 2015). Numerous contributions gave an overview of the growing HELM ecosystem and its adoption by the pharmaceutical industry.

Calling developers and informaticians!

Test your creativity and take on one of these HELM-related challenges. Each one is conceptually interesting and should be fun to solve.

What is HELM?

HELM (Hierarchical Editing Language for Macromolecules) enables the representation of a wide range of biomolecules...

proteins,
nucleotides,
antibody drug conjugates,
etc.

...whose size and complexity render existing small-molecule and sequence-based informatics methodologies impractical or unusable.

Why HELM Notation?

  • Supports all biomolecules in a single notation
  • Facilitates information exchange between organisations
  • Compact and flexible

Download the free toolkit, editors and more

Also available: search proof of concept and starter pack of monomers.

  • Create your own applications using the functionality in the toolkit.
  • Draw and convert structures into HELM using the editor.
  • Visualise antibodies, manipulate the structures and analyse domains using HAbE.
  • Source code and compiled versions available

Community

HELM relies on an active voluntary community. We are currently supported by the following companies.

Contact Us

Ask us questions, send comments, get in touch. We love to support HELM adopters.

Resources

Links to the HELM code, user guides, videos, specifications and more can be found on our wiki.