Project participants: Simon Thornber (GSK, project lead), Giles Ratcliffe (Pathforwards Ltd., project analyst), GSK, AstraZeneca, Lundbeck, Novartis, Roche
Capitalizing on sequencing data has required life science organizations to build and maintain infrastructure and associated workflows to search gene repositories. But such infrastructure confers little competitive advantage. And maintaining a core set of sequence databases and associated tools requires, as the Red Queen told Alice, "all the running you can do to keep in the same place"
The sequence services project aimed to define and demonstrate shared, hosted services for securely storing and mining both proprietary and public domain gene databases. Through two project phases, the effort developed securely managed services that would provide subscribers the following benefits:
The team selected four vendors to provide proofs of concept of the Phase 1 requirements. The resulting systems were publicly demonstrated and published in April 2011 after testing and ethical hacking by AT&T. The findings were written up in GIT Laboratory Journal.
Cognizant and Eagle Genomics
Cognizant and Eagle have built a secure hosted platform to deliver a Phase 1 proof of concept of the Pistoia Alliance sequence services project. The phase 1 platform delivers Ensembl, Plasmapper, and a Gene Alias service. The platform was ethically hacked by AT&T and found to be secure except for few minor modifications to some security settings.
Constellation Technologies and Microsoft
Infosys developed a secure hosted platform of trusted federated workspaces. User logins are authenticated with corporate identity, enabling scientists to access post-genomic data management services that can be scaled for performance to provide a controlled view of the public-private data interlink.