Find out how HELM can transform your storage of molecule information
Reference implementation
The power of HELM shown in a range of free tools
Join the project or connect with experts who can help you adopt HELM
Try the HELM Editor and HAbE, and find specifications, links to the code, user guides & presentations

Recent HELM Updates

HELM Antibody Editor released

The release of the HELM Editor by the Pistoia Alliance in 2014 inspired a team at Roche and quattro research to use this technology for the registration of antibodies engineered at Roche’s research sites.

ChEMBL 20 takes the HELM

ChEMBL 20 incorporates the Hierarchical Editing Language for Macromolecules (HELM), the macromolecular representation standard recently released by the Pistoia Alliance.

ChemAxon Biomolecule Toolkit includes HELM compatibility

ChemAxon, a Pistoia Alliance member, has today released its new Biomolecule Toolkit product. The Biomolecule Toolkit includes HELM compatibility making it fully interoperable with an increasing number of other HELM-aware solutions and adopters.

HELM Phase 1 Exceeded Expectations

The Pistoia Alliance HELM project started almost two years ago in December 2012 when David Klatte proposed that the Pistoia Alliance help open source a technology first developed for internal use at Pfizer. That technology was HELM and it enabled the representation of complex macromolecules. The Pistoia Alliance membership enthusiastically embraced the idea and the HELM project was born.

Calling developers and informaticians!

Test your creativity and take on one of these HELM-related challenges. Each one is conceptually interesting and should be fun to solve.

What is HELM?

HELM (Hierarchical Editing Language for Macromolecules) enables the representation of a wide range of biomolecules...

antibody drug conjugates,

...whose size and complexity render existing small-molecule and sequence-based informatics methodologies impractical or unusable.

Why HELM Notation?

  • Supports all biomolecules in a single notation
  • Facilitates information exchange between organisations
  • Compact and flexible

Download the free toolkit, editors and more

Also available: search proof of concept and starter pack of monomers.

  • Create your own applications using the functionality in the toolkit.
  • Draw and convert structures into HELM using the editor.
  • Visualise antibodies, manipulate the structures and analyse domains using HAbE.
  • Source code and compiled versions available


HELM relies on an active voluntary community. We are currently supported by the following companies.

Contact Us

Ask us questions, send comments, get in touch. We love to support HELM adopters.


Links to the HELM code, user guides, videos, specifications and more can be found on our wiki.