Hierarchical Editing Language for Macromolecules (HELM)

Overview

HELM (Hierarchical Editing Language for Macromolecules) enables the representation of a wide range of biomolecules including proteins, nucleotides and antibody drug conjugates, whose size and complexity render existing small-molecule and sequence-based informatics methodologies impractical or unusable. HELM is compact and flexible.

The project created a suite of HELM open source tools:

• Web-editor for drawing structures, connecting monomers and calculating properties
• Antibody editor for visualizing antibody domains, managing quaternary structures and performing automatic reactions
• Toolkit for creating personalized applications

HELM has been widely adopted across the biopharmaceutical industry.