• Home
  • Join the Alliance
    • About Us
    • Our Members
    • Become a Member
    • Join the PA Team
  • Join A Project
    • All Projects
    • Chemical Safety Library Project
    • DataFAIRy Bioassay Annotation Project
    • Diversity & Inclusion in STEM Leadership Program
    • FAIR Implementation Project
    • IDMP Ontology Project
    • Microbiome Project
    • Natural Language Processing Use Case Database Project
    • Semantic Enrichment of ELN Data Project
  • Join a Community
    • All Communities
    • Artificial Intelligence & Machine Learning
    • Clinical Trial Environmental Impact
    • Controlled Substance Compliance
    • Lab of the Future
    • Pistoia Alliance/FDA In Vitro Pharmacology
    • Quantum Computing
    • Social Media & Real-World Evidence
    • User Experience for Life Sciences
  • Submit an Idea
  • Events
    • All events
    • Submit an Event
    • Sponsor a Webinar
    • Global Knowledge-Sharing Events
    • Past Webinars
  • News

  • Home
  • Join the Alliance
    • About Us
    • Our Members
    • Become a Member
    • Join the PA Team
  • Join A Project
    • All Projects
    • Chemical Safety Library Project
    • DataFAIRy Bioassay Annotation Project
    • Diversity & Inclusion in STEM Leadership Program
    • FAIR Implementation Project
    • IDMP Ontology Project
    • Microbiome Project
    • Natural Language Processing Use Case Database Project
    • Semantic Enrichment of ELN Data Project
  • Join a Community
    • All Communities
    • Artificial Intelligence & Machine Learning
    • Clinical Trial Environmental Impact
    • Controlled Substance Compliance
    • Lab of the Future
    • Pistoia Alliance/FDA In Vitro Pharmacology
    • Quantum Computing
    • Social Media & Real-World Evidence
    • User Experience for Life Sciences
  • Submit an Idea
  • Events
    • All events
    • Submit an Event
    • Sponsor a Webinar
    • Global Knowledge-Sharing Events
    • Past Webinars
  • News
Become a Member
Search

Search...

  • Menu

Chemical Safety Webinar

Extracting Adverse Event Incidence Rates for Predictive Toxicology

Webinar Summary

Drugs can cause unwanted undesirable effects called adverse reactions, or side effects. In addition to lack of drug efficacy, safety issues caused by these reactions are a major reason for clinical trials to fail. Identifying adverse reactions in preclinical stages can help to reduce the risk associated with drug development and improve patient safety.

In-vitro and in-silico predictive toxicology models can be used to identify adverse reactions at an early development stage. However, they require reliable, quantitative data on adverse event incidence rates for calibration and training. While a great deal of clinical and regulatory information on adverse drug events is publicly available, the data itself is often unstructured, limiting its accessibility. The variety of ways in which the relevant information is reported provides a challenge for data extraction at scale.

Using a test set of 865 FDA-approved small molecule drugs, we demonstrate a workflow for extracting adverse reaction incidence rates from clinical trials, drug labels and literature. To ensure statistical robustness and comparability between drugs, we identify patient numbers and the monotherapy status of the underlying trials. Using a combination of public and proprietary natural language processing tools, we supplement the extracted incidence rates with dosage, route of administration and formulation data. To compare the results from clinical trials with data from post-market reports, we perform a disproportionality analysis using FAERS data. In this webinar, we will present our approach to solving the challenges in data collection and summarize the top results from both search strategies, using gastrointestinal toxicity as an example.

 

Interested in Joining the Pistoia Alliance?

There has never been a more important time to collaborate to innovate as an industry! If you would like to find out more about the benefits of Pistoia Alliance membership and how you can get involved with all the different initiatives we run, please send an email to Membership@PistoiaAlliance.org.

Access the Recording

We will email you the recording.

Posted on October 6, 2022 by Melanie Hardcastle
Categories: Chemical Safety, Controlled Substance, Pharmacology, Pistoia Webinars

Tags: data governance, data science, data standards, webinar


Events

23 Mar 2023

CCDC Webinar: Scaffold Hopping for Digital Drug Design

Book this event >
29 Mar 2023

How important is subject matter expertise in Life Sciences when using technology and artificial intelligence?

Book this event >
05 Apr 2023

Good Machine Learning Practices by the Pistoia Alliance GMLP CoI

Book this event >
18 Apr 2023

Pistoia Alliance Annual Spring Conference

London United Kingdom
Book this event >
Follow Us
Featured Projects
Natural Language Processing (NLP) Use Case Database Project
IDMP Ontology Project
Diversity & Inclusion in STEM Leadership Program
Unified Integrated Knowledge Base
Microbiome Project
Data Visualization Project
Methods Hub Project
Informed Consent Blockchain Project
Quality Generation and Ethical Use of Digital Health Data in Clinical Studies
Semantic Enrichment of ELN Data Project (SEED)
Sign up for Pistoia Alliance Communications

© Copyright Pistoia Alliance, Inc., 2020 | Contact us at info@pistoiaalliance.org | Terms of use | Privacy Statement

By clicking "Agree" you are agreeing to the following terms and conditions for the use of the UDM XML Schema definition.

This website intends to use cookies to improve the site and provide you with a better browsing experience. If you select "Continue" or continue to browse the site without customizing your choices, you agree to our use of cookies. Find out more in our Online Privacy Statement.

Continue More Info